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Memorial Sloan Kettering Cancer Center

Tabelecleucel (tab-cel^®)*

In 2015, �ڽ���Ƶ entered into a worldwide license agreement with Memorial Sloan Kettering Cancer Center (MSK) for the development, manufacturing, and commercialization of allogeneic T-cell immunotherapies developed in the lab of Dr. Richard O’Reilly for the treatment of certain cancers and persistent viral infections. Under the terms of the agreement, we acquired the rights to tab-cel^®, which is currently completing a registrational study for the treatment of EBV+ PTLD, and a Phase 2 study for additional EBV-driven malignancies.

Next Generation CAR T

In 2018, we expanded our collaboration with Memorial Sloan Kettering Cancer Center (MSK) to develop the next generation of genetically engineered chimeric antigen receptor T-cell (CAR T) immunotherapies. We gained access to several of MSK’s innovative enabling technologies, including a novel co-stimulatory domain (1XX) that may have physiologic T-cell activation properties, as well as methods for designing CAR T immunotherapies. Under the agreement, �ڽ���Ƶ has also entered into an exclusive research collaboration for multiple targets with Michel Sadelain, M.D., Ph.D., Director, Center for Cell Engineering at MSK, to employ next-generation technologies in developing novel CAR T immunotherapies with potential applications in oncology, autoimmune and infectious diseases.

Mesothelin CAR T

In 2018, we also entered a research collaboration and licensed worldwide rights to mesothelin-targeted chimeric antigen receptor T-cell (CAR T) immunotherapies for solid tumors developed in the lab of Dr. Prasad Adusumilli. The most advanced program in �ڽ���Ƶ’s CAR T collaboration with MSK is focused on the development of a next-generation, mesothelin-targeted CAR T using novel 1XX CAR signaling domain and PD-1 dominant negative receptor (DNR) checkpoint inhibition technologies for patients with mesothelin-associated solid tumors.

QIMR Berghofer

In 2015, we obtained an exclusive, worldwide license to develop and commercialize allogeneic, or “off-the-shelf”, T-cell immunotherapies directed against multiple epitopes of the Epstein-Barr virus (EBV) utilizing technology developed by Dr. Rajiv Khanna at QIMR Berghofer. Initial application of the technology includes �ڽ���Ƶ’s Phase 2 candidate ATA188, currently being investigated for the treatment of certain autoimmune disorders such as multiple sclerosis (MS). We have also expanded the collaboration to include research and development of additional programs, which include targeting human papillomavirus (HPV).

Moffitt Cancer Center

In 2018, we entered into a license agreement and strategic collaboration with Moffitt Cancer Center to develop multi-targeted chimeric antigen receptor T-cell (CAR T) immunotherapies for patients with AML and B-cell malignancies developed by Dr. Marco Davila. As part of the collaboration, �ڽ���Ƶ also gained exclusive access to novel CAR T targeting and co-stimulation domains designed to improve T-cell proliferation and enhance persistence. This agreement furthers the Company’s strategy to develop next-generation engineered CAR T immunotherapies across multiple therapeutic areas and leverage the Company’s off-the-shelf, allogeneic T-cell immunotherapy platform.

Bayer

In 2020, �ڽ���Ƶ and Bayer entered into an exclusive worldwide license agreement and research, development, and manufacturing collaboration for mesothelin-directed CAR T-cell therapies for the treatment of solid tumors. The agreement includes the development candidate ATA3271, an armored allogeneic T-cell immunotherapy, and an autologous version, ATA2271, for high mesothelin-expressing tumors such as malignant pleural mesothelioma and non-small-cell lung cancer. The licensed technology leverages �ڽ���Ƶ´s novel, proprietary Epstein-Barr Virus (EBV) T-cell platform combined with CAR T technologies targeting mesothelin with the goal to improve efficacy, persistence, safety, and durability of response.

CareDx

In 2020, �ڽ���Ƶ entered into a research collaboration with CareDx to develop a novel and precise Next Generation Sequencing (NGS) method for detection and quantitation of allogeneic T cells in peripheral blood and described its use in non-engineered allogeneic T cells. This method offers potential applications in correlating pharmacokinetic (PK) profiles for non-engineered T cells (such as tab-cel^® and ATA188) with response and other endpoints of interest to clinical development.

Pierre Fabre

In 2021, �ڽ���Ƶ and Pierre Fabre entered a strategic collaboration to commercialize tabelecleucel (tab-cel^®)* in Europe, Middle East, Africa, and other select emerging markets for Epstein-Barr virus (EBV) positive cancers. �ڽ���Ƶ retained full rights to tab-cel^® in other major markets, including North America, Asia Pacific, and Latin America. The Companies’ complementary capabilities will help expand access to tab-cel^® to patients worldwide who suffer from EBV+ post-transplant lymphoproliferative disease (PTLD) and other EBV-driven cancers.

*Tabelecleucel is an investigational agent and is not approved by any regulatory agencies as a treatment for any indication. Efficacy and safety have not been established. There is no guarantee that tabelecleucel will become commercially available.